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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-Raf1-S259 antibody produced in rabbit

Anti-Phospho-Raf1-S259 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700372
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
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服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Phospho-Raf1-S259 antibody produced in rabbit
RAF1
Raf-1
CMD1NN
C-RAF
NS5
CRAF
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

免疫原

A synthetic phosphorylated peptide around S259 of human RAF1 (NP_002871.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 73
75
species reactivity human, mouse
浓度 4.95 mg/ml
technique(s) immunoprecipitation (IP): 1:50-1:100
western blot: 1:500-1:2000
UniProt登记号 P04049
运输 wet ice
储存温度 ?20℃
Gene Information human ... RAF1(5894)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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