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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-PTEN-S380 antibody produced in rabbit

Anti-Phospho-PTEN-S380 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700549
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Phospho-PTEN-S380 antibody produced in rabbit
MHAM
GLM2
PTENbeta
10q23del
CWS1
BZS
PTEN
DEC
TEP1
PTEN1
MMAC1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

免疫原

A phospho specific peptide corresponding to residues surrounding S380 of human PTEN

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 47
species reactivity mouse, human, rat
浓度 2.79mg/ml
technique(s) western blot: 1:500-1:2000
UniProt登记号 P60484
运输 wet ice
储存温度 ?20℃
Gene Information human ... PTEN(5728)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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