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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-PTEN-S380 antibody produced in rabbit

Anti-Phospho-PTEN-S380 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701839
包装型号
规格纯度
价格
5406.77 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Phospho-PTEN-S380 antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

免疫原

A phospho specific peptide corresponding to residues surrounding S380 of human PTEN

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
antibody product type primary antibodies
克隆 monoclonal
形式 liquid
species reactivity human
浓度 1.4 mg/mL
technique(s) western blot: 1:500-1:2000
UniProt登记号 P60484
运输 wet ice
储存温度 ?20℃
Gene Information human ... PTEN(5728)

安全信息

闪点(F) Not applicable
闪点(C) Not applicable

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