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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-PRKACA-T197 antibody produced in rabbit

Anti-Phospho-PRKACA-T197 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700403
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-Phospho-PRKACA-T197 antibody produced in rabbit
PKACA
PPNAD4
PRKACA
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing′s syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

免疫原

A synthetic phosphorylated peptide around T197 of human PRKACA (NP_002721.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 39
40
species reactivity mouse, rat, human
浓度 2.53 mg/ml
technique(s) western blot: 1:500-1:2000
UniProt登记号 P17612
运输 wet ice
储存温度 ?20℃
Gene Information human ... PRKACA(5566)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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