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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-PPP1R12A-S507 antibody produced in rabbit

Anti-Phospho-PPP1R12A-S507 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700445
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
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服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Phospho-PPP1R12A-S507 antibody produced in rabbit
PPP1R12A
M130
MYPT1
MBS
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

免疫原

A synthetic phosphorylated peptide around S507 of human PPP1R12A (NP_001137357.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 105
109
111
115
species reactivity human
浓度 1.68 mg/ml
technique(s) western blot: 1:500-1:2000
UniProt登记号 O14974
运输 wet ice
储存温度 ?20℃
Gene Information human ... PPP1R12A(4659)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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