半岛bd体育手机客户端 说明
一般描述
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
免疫原
A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.
外形
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | liquid |
| species reactivity | human, mouse |
| 浓度 | 0.464 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt登记号 | Q8NB16 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... Phospho-MLKL-S454(197259) |
安全信息
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
