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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-ERBB2-Y1248 antibody produced in rabbit

Anti-Phospho-ERBB2-Y1248 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700420
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Phospho-ERBB2-Y1248 antibody produced in rabbit
HER2
MLN19
CD340
HER-2/neu
TKR1
ERBB2
HER2/ErbB2
NGL
erb-b2 receptor tyrosine kinase 2
HER-2
NEU
MLN 19
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

免疫原

A synthetic phosphorylated peptide around Y1248 of human ERBB2 (NP_004439.2).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 134
136
137
62
70
97
species reactivity human
浓度 0.71 mg/ml
technique(s) western blot: 1:500-1:2000
UniProt登记号 P04626
运输 wet ice
储存温度 ?20℃
Gene Information human ... ERBB2(2064)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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