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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-Cyclin E1-T77 antibody produced in rabbit

Anti-Phospho-Cyclin E1-T77 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701851
包装型号
规格纯度
价格
5406.77 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Phospho-Cyclin E1-T77 antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

免疫原

A phospho specific peptide corresponding to residues surrounding T77 of human Cyclin E1

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
antibody product type primary antibodies
克隆 monoclonal
形式 liquid
species reactivity human
浓度 2 mg/mL
technique(s) western blot: 1:500-1:2000
UniProt登记号 P24864
运输 wet ice
储存温度 ?20℃
Gene Information human ... CCNE1(898)

安全信息

闪点(F) Not applicable
闪点(C) Not applicable

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