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Anti-phospho-CD3ζ (pTyr142) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200334
规格纯度
~1.0 mg/mL, affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-CD3ζ (pTyr 142) antibody produced in rabbit
Anti-CD3Z
Anti-T3Z
Anti-CD3h
Anti-T cell receptor T3 zeta chain
Anti-CD247
Anti-CD3Q
Anti-TCRZ
Anti-TCRK
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The TCR-CD3 multimeric complex is composed of TCRαβ, CD3γε and CD3δε and TCR‐ζ homodimer. The CD3γ, CD3δ and CD3ε, each contain one immunoreceptor tyrosine-based activation motif (ITAM), whereas the ζ chain contains three ITAMs.

免疫原

synthetic phosphopeptide corresponding to residues surrounding Tyr142of mouse CD3ζ, conjugated to KLH. The corresponding sequence is identical in human CD3ζ.

应用

Anti-phospho-CD3ζ (pTyr142) antibody produced in rabbit has been used in several immunochemical techniques including immunoblotting and immunoprecipitation.

生化/生理作用

Amongst the TCR subunits, the CD3 ζ chain plays a key role in regulating TCR assembly, transport, and cell surface expression. Down-regulation of TCR ζ chain expression associated with T cell dysfunction was described in various pathologies.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity mouse
浓度 ~1.0 mg/mL
technique(s) immunoprecipitation (IP): 1-2 μg using lysates of HEK-293T cells co-expressing mCD3? and constitutively active LCK.
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells co-expressing mCD3? and constitutively active LCK.
UniProt登记号 P24161
运输 dry ice
储存温度 ?20℃
Gene Information human ... CD247(919)
mouse ... Cd247(12503)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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