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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-BRCA1-S1524 antibody produced in rabbit

Anti-Phospho-BRCA1-S1524 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700376
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-Phospho-BRCA1-S1524 antibody produced in rabbit
FANCS
BRCA1
PNCA4
BRCC1
IRIS
BROVCA1
RNF53
BRCAI
PPP1R53
PSCP
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

免疫原

A synthetic phosphorylated peptide around S1524 of human BRCA1 (NP_009225.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 202-210
78-85
7
species reactivity mouse, rat, human
浓度 0.57mg/ml
technique(s) western blot: 1:500-1:2000
UniProt登记号 P38398
运输 wet ice
储存温度 ?20℃
Gene Information human ... BRCA1(672)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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