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位置: 首页> 品牌> Sigma-Aldrich> Aβ peptide, Ser26 phosphorylated, Abeta peptide, Ser26 phosphorylated, Amyloid β peptide, Ser26 phosphorylated, Aβ1-40, Ser26 phosphorylated, Aβ1-42, Ser26 phosphorylated, Abeta1-40, Ser26 phosphorylated, Abeta1-42, Ser26 phosphorylat

Anti-phospho-Amyloid beta Antibody (Ser26), clone 5H11C10

Aβ peptide, Ser26 phosphorylated, Abeta peptide, Ser26 phosphorylated, Amyloid β peptide, Ser26 phosphorylated, Aβ1-40, Ser26 phosphorylated, Aβ1-42, Ser26 phosphorylated, Abeta1-40, Ser26 phosphorylated, Abeta1-42, Ser26 phosphorylat

品牌
Sigma-Aldrich
货号
MABN879
规格纯度
clone 5H11C10, from mouse
价格
4765.68 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-Amyloid beta Antibody (Ser26), clone 5H11C10
Aβ peptide, Ser26 phosphorylated, Abeta peptide, Ser26 phosphorylated, Amyloid β peptide, Ser26 phosphorylated, Aβ1-40, Ser26 phosphorylated, Aβ1-42, Ser26 phosphorylated, Abeta1-40, Ser26 phosphorylated, Abeta1-42, Ser26 phosphorylat
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Amyloid beta A4 protein (UniProt P05067; also known as ABPP, Alzheimer disease amyloid protein, Amyloid precursor protein, APP, APPI, Cerebral vascular amyloid peptide, CVAP, PN-II, PreA4, Protease nexin-II) is encoded by the APP (also known as A4, AD1) gene (Gene ID 351) in human. Amyloid precursor protein (APP) is initially produced with a signal peptide sequence (a.a. 1-17), the removal of which yields the mature protein with a large extracellular portion (a.a. 18-699), followed by a transmembrane segment (a.a. 700-723) and a cytoplasmic (a.a. 724-770) tail. APP can be further processed by the α-, β-, and γ-secretases in two alternative processing pathways. In the non-amyloidogenic pathway, APP is first cleaved by the plasma membrane-localized α-secretase to generate an N-terminal extracellular sAPPα fragment (a.a. 18-687) and a membrane-bound C-terminal fragment C83 (CTFα), which can be further cleaved by γ-secretase to produce a non-toxic small peptide p3 and a cytoplasmic APP intracellular domain (AICD). In the amyloidogenic pathway, APP undergoes β-cleavage in BACE-1 (β-site APP-cleaving enzyme)-enriched endosomes to generate an N-terminal extracellular sAPPβ fragment (a.a. 18-671) and a membrane-bound C-terminal fragment C99 (CTFβ). Subsequent cleavage of C99 by γ-secretase releases the amyloid β peptides, Aβ1-42 (672-713) & Aβ1-40 (672-711), and AICD. Aβ accumulation in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer′s disease (AD). Aβ serine phosphorylation is shown to promote Aβ aggregation into oligomeric and fibrillar assemblies and to prevent Aβ proteolytic clearance by certain proteases.

特异性

Clone 5H11C10 recognizes Aβ1-40 and Aβ1-42 peptides with phosphorylated Ser26, but not the non-phosphorylated peptides.

免疫原

KLH-conjugated linear peptide corresponding to human amyloid beta peptide target region sequence with phosphorylated Ser26.

应用

Western Blotting Analysis: 2 ?g/mL from a representative lot detected monomeric and dimeric forms of synthetic A 1-40 peptide with phosphorylated Ser26, but not the non-phosphorylated A 1-40 peptide (Courtesy of Dr. Kumar Sathish, University of Bonn, Germany)

Western Blotting Analysis: 2 ?g/mL from a representative lot detected Ser26-phosphorylated oligomeric amyloid beta (pA ) peptides in brain extracts from 8-month old APP/PS1KI transgenic mice, but not in extracts from age-matched non-transgenic mice (Courtesy of Dr. Kumar Sathish, University of Bonn, Germany).

Note: Formic acid (88%) treatment following heat retrieval is recommended for immunohistochemical detection of aggregated intraneuronal Abeta peptides in brain sections (Kumar, S., et al. (2013). Acta Neuropathol. 125(5):699-709; Christensen, D.Z., et al. (2009). Brain Res. 1301:116-125).
Anti-phospho-Amyloid beta (Ser26), clone 5H11C10, Cat. No. MABN879, is a highly specific mouse monoclonal antibody, that targets amyloid beta peptides Ser26 phosphorylation and has been tested in ELISA, Immunofluorescence, Western Blotting.

质量

Identity Confirmation by Isotyping Test.

Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be IgG1κ.

目标描述

~4/8 (monomer/dimer) and >188 (oligomer) kDa observed. 4.514/9.028 kDa (Abeta1-42 monomer/dimer), 4.330/8.660 kDa (Abeta1-40 monomer/dimer) calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Protein G purified.
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 5H11C10, monoclonal
species reactivity human
technique(s) ELISA: suitable
immunofluorescence: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_000475
UniProt登记号 P05067
运输 ambient
Gene Information human ... APP(351)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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