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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho-Akt-S473 antibody produced in rabbit

Anti-Phospho-Akt-S473 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701947
包装型号
规格纯度
价格
4266.29 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Phospho-Akt-S473 antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

免疫原

A phospho specific peptide corresponding to residues surrounding S473/S474/S472 of human AKT1/AKT2/AKT3

外形

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
antibody product type primary antibodies
克隆 monoclonal
形式 liquid
species reactivity human, rat
浓度 1 mg/mL
technique(s) western blot: 1:500-1:2000
UniProt登记号 P31749/P31751/Q9Y243
运输 wet ice
储存温度 ?20℃

安全信息

闪点(F) Not applicable
闪点(C) Not applicable

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