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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho Histone H3 (Ser10), clone 6G8B7 Antibody

Anti-phospho Histone H3 (Ser10), clone 6G8B7 Antibody

品牌
Sigma-Aldrich
货号
MABE939
规格纯度
clone 6G8B7, 1 mg/mL, from rat
价格
6127.14 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho Histone H3 (Ser10), clone 6G8B7 Antibody
H3S10P, Histone H3 (phospho Ser10), H3 histone, family 3A, H3.3A, H3 histone, family 3B, H3.3B
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone H3 variants (H3.1, H3.2 and H3.3) have been implicated in the epigenetic memory of cellular state. Genome-wide patterns of H3.3 are dependent on amino acid sequence and change with cellular differentiation at developmentally regulated loci.

免疫原

KLH-conjugated linear peptide corresponding to human Histone H3 (Ser10).

应用

Research Sub Category
Nuclear Receptors
This Anti-phospho Histone H3 (Ser10), clone 6G8B7 Antibody is validated for use in Western Blotting and Immunocytochemistry and ELISA for the detection of phospho Histone H3 (Ser10).
Immunocytochemistry Analysis: A 1:5000 dilution from a representative lot detected Histone H3 (Ser10) in HeLa cells (Prof. Taro Tachibana, Osaka City University).
ELISA Analysis: A representative lot detected Histone H3 (Ser10) using differently phosphorylated and unphosphorylated peptides unmodified H3, H3 S10ph, and H3 S28ph (Prof. Taro Tachibana, Osaka City University).
Research Category
Epigenetics & Nuclear Function

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected Histone H3 (Ser10) in 10 ?g of nocodazole treated HeLa cell lysates.

目标描述

~17 kDa observed

联系

Replaces: 04-1093

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
抗体形式 purified antibody
antibody product type primary antibodies
克隆 6G8B7, monoclonal
species reactivity human
浓度 1 mg/mL
technique(s) ELISA: suitable
immunocytochemistry: suitable
western blot: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NP_002098
UniProt登记号 P84243
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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