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位置: 首页> 品牌> Sigma-Aldrich> Anti-Pericentrin Antibody

Anti-Pericentrin Antibody

品牌
Sigma-Aldrich
货号
ABT59
规格纯度
from rabbit, purified by affinity chromatography
价格
5854.74 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-Pericentrin Antibody
Pericentrin, Kendrin, Pericentrin-B
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Pericentrin binds to calmodulin and is expressed in the centrosome that serves as a multifunctional scaffold for anchoring proteins and protein complexes. Evidence suggests that pericentrin plays a role in microtubule nucleation and spindle organization. Recent studies show pericentrin plays a role in Majewski/micorcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel Syndrome. Recent use in network modeling indicates a direct link between breast cancer susceptibility to centrosome defects. Pericentrin is a potential marker for centrosome defects in cancer and cancer progression, as centrosomal abonormalities in solid tumors are accompanied by increased pericentrin levels and defects in pericentrin organization.

特异性

Other homologies: Mouse (89% sequence homology). No homology to Rat was found.

免疫原

KLH-conjugated linear peptide corresponding to human Pericentrin.

应用

This Anti-Pericentrin Antibody is validated for use in WB, IC for the detection of Pericentrin.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Pericentrin in HeLa cells.

质量

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 ?g/mL of this antibody detected Pericentrin in 10 ?g of HeLa cell lysate. Western Blot was performed without Tween.

目标描述

~250 kDa observed.
Uniprot describes 2 isoforms produced by alternative splicing with molecular weights at 378 & 355 kDa However in endogenous lysates, Pericentrin is observed at ~250 kDa & ~150 kDa for western blots (Wen, Y., et al. (2008). J Biol Chem. 283(5):2793-2803).

外形

Affinity purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunocytochemistry: suitable
western blot: suitable
NCBI登记号 NP_006022
UniProt登记号 O95613
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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