Anti-PCBP1

半岛bd体育手机客户端 说明

一般描述

Poly(rC) binding protein 1 (PCBP1) is a RNA binding protein. The gene is located on human chromosome 2p13.3. PCBP1 is known as a cytosolic iron chaperone

免疫原

Synthetic peptide directed towards the middle region of Human PCBP1

生化/生理作用

Poly(rC) binding protein 1 (PCBP1) appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This intron less gene is thought to be generated by retro transposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.
PCBP1 functions as a tumor suppressor in prostate epithelial cells by blocking MAPK1 (Mitogen-activated protein kinase 1) expression. It is a potential therapeutic target for colorectal cancer. Mutations in PCBP1 is linked to Burkitt lymphoma. PCBP1 transports iron to ferritin. It also acts a tumor suppressor.

序列

Synthetic peptide located within the following region: PHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVARQQSHFAMMHGGTGF

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	37 kDa
species reactivity	guinea pig, bovine, mouse, horse, dog, human, rabbit, rat
浓度	0.5-1 mg/mL
technique(s)	immunoblotting: suitable immunohistochemistry: suitable
登记号	NM_006196
UniProt登记号	Q15365
运输	wet ice
储存温度	?20℃
Gene Information	human ... PCBP1(5093)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable