Anti-PATE1 Antibody

半岛bd体育手机客户端 说明

一般描述

PATE1 is a secreted protein that is expressed exclusively in the prostate and testis and is up regulated in the prostate epithelial cells during cancer. Because of the extreme specificity of PATE1 expression it makes it a potential target for immunotherapy in prostate cancer. PATE1 is the founding member of new syntenic loci in humans and mice that encode secreted proteins that have 10 cysteine residues. The PATE family has three-fingered protein/Ly-6/urokinase-type plasminogen activator receptor (uPAR) domains that shape three-fingered proteins (TFPs). Additional members include PATE-M, PATE-DJ, and PATE-B that are also expressed in prostate and testis and sperm. Related proteins, PATE-P and PATE-Q are expressed only in placenta. Research indicates that PATE proteins may have something to do with fertility and recent research showed that addition PATE-like genes were expressed in neuron-rich tissues and thus may have a role in neurological function or transmission.

免疫原

GST-tagged recombinant protein corresponding to human PATE1.

应用

Research Sub Category
Apoptosis - Additional
This Anti-PATE1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of PATE1.
Research Category
Apoptosis & Cancer
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PATE1 in human testis and human hyperplastic prostate tissue.

质量

Evaluated by Western Blotting in rat testis tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected PATE1 in 10 ?g of rat testis tissue lysate.

目标描述

~14 kDa observed

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human, rat
species reactivity (predicted by homology)	mouse (based on 70% sequence homology)
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
NCBI登记号	NP_612151
UniProt登记号	Q8WXA2
运输	wet ice
Gene Information	human ... PATE1(160065)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable