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Anti-PAR-1, clone ATAP2 Antibody

品牌
Sigma-Aldrich
货号
MABF244
规格纯度
clone ATAP2, from mouse
价格
5016.79 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-PAR-1, clone ATAP2 Antibody
Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The protein named Proteinase-activated receptor 1 (PAR-1/PAR1) or Coagulation factor II receptor, or Thrombin receptor and encoded by the human gene F2R/CR2R/PAR1/TR is a high affinity receptor for activated thrombin and part of the innate immune system response driven by proteinase-activated receptors (PARs). PARs are G protein-coupled receptors that transmit cellular responses to extracellular proteases and have important functions in vascular physiology, development, inflammation, and cancer progression. PAR1 is important for platelet activation and vascular development. PAR1 expression is limited to platelets and vascular endothelial cells and is localized to the cell membrane. Interestingly too, even the signal peptide of PAR1 (which guides the protein to the membrane) plays a role in cell signaling as if forms the intracellular angiogenesis inhibitor peptide Parstatin.

免疫原

Linear peptide corresponding to human Par-1.

应用

This Anti-PAR-1 antibody, clone ATAP2 is validated for use in western blotting, flow cytometry, ICC & immunofluorescence for the detection of PAR-1.
Flow Cytometry Analysis: 4 ?g from a representative lot detected Par-1 in 1X10E6 human thrombocytes (platelets).

Flow Cytometry Analysis: A representative lot from an independent laboratory detected Par-1 in CHRF-288 and HEL cells (Hoxie, J. A., et al. (1993). J Biol Chem. 268(18):13756-13763.).

Western Blotting Analysis: A representative lot from an independent laboratory detected Par-1 in human platelet membrane cell lysate (Brass, L. F., et al. (1992). J Biol Chem. 267(20):13795-13798.).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Par-1 in CHRF-288 and HEL cells (Hoxie, J. A., et al. (1993). J Biol Chem. 268(18):13756-13763.).

Immunofluorescence Analysis: A representative lot from an independent laboratory detected Par-1 in CHRF-288 cells (Brass, L. F., et al. (1994). J Biol Chem. 269(4):2943-2952.).

质量

Evaluated by Western Blotting in mouse lymph node tissue.

Western Blotting Analysis: 1 ?g/mL of this antibody detected Par-1 in 10 ?g of mouse lymph node tissue.

目标描述

~50 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 ATAP2, monoclonal
species reactivity human, mouse
technique(s) flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_001983
UniProt登记号 P25116
运输 wet ice
Gene Information human ... F2R(2149)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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