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Anti-PACSIN2 (C-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300127
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
5045.46 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-PACSIN2 (C-term) antibody produced in rabbit
Anti-Protein kinase C and casein kinase substrate in neurons protein 2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Protein kinase C and casein kinase substrate in neurons 2 (PACSIN2), also termed syndapin II exhibits a vesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). The protein contains EFC/F-BAR (Fes/CIP4 homology - Bin/amphiphysin/Rvs ) domain (1 FCH domain) and 1 SH3 (Src homology 3) domain. In human chromosome, the gene PACSIN2 is localized on 22q13.2.

免疫原

PACSIN2 (NP_009160, 347-381)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PACSIN2.

应用

Anti-PACSIN2 (C-term) antibody produced in rabbit has been used in immunostaining.

生化/生理作用

Protein kinase C and casein kinase substrate in neurons 2 (PACSIN2) may play a role in vesicle formation and transport and organization of cytoskeleton. This protein homo- and hetero-aggregates with other PACSINs and thus acts as membrane associated adapter protein. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). Pacsin2 is crucial for the formation and maintenance of kidney associated tubules. Pacsin2 is involved with caveolae biogenesis in plasma membrane. Pacsin2 regulates cell migration and spreading by binding with Rac1 (Ras-related C3 botulinum toxin substrate 1) protein. Pacsin2 is involved in microspike formation and tubulation like filopodia, lamellopodia in the cell.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human, mouse
technique(s) immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
indirect immunofluorescence: 1:10-1:50
western blot: 1:100-1:500
NCBI登记号 NP_009160
UniProt登记号 Q9UNF0
运输 dry ice
储存温度 ?20℃
Gene Information human ... PACSIN2(11252)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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