半岛bd体育手机客户端 说明
一般描述
Phosphofurin acidic cluster sorting protein 2 (PACS2), also known as PACS-2, PACS1-like protein, and encoded by the gene name PACS2/ KIAA0602/ PACS1L, is a amember of the PACS family. PACS2 is a multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally, PACS2 translocates BIB to mitochondria in response to apoptic inducers, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome C, and the activation of caspase-3 thereby causing cell death. Recent studies have indicated that PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. PACS2 interacts with BID, PKD2, and HIV-1 Nef.
免疫原
GST-tagged recombinant protein corresponding to Human PACS2.
应用
Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: A 1:500 dilution from a representative lot detected PACS2 in 10 ?g of mouse hypothalamus tissue.
Research Category
Apoptosis & Cancer
This Anti-PACS2 antibody is validated for use in Western Blotting for the detection of PACS2.
质量
Evaluated by Western Blotting in rat hippocampus tissue lysate.
Western Blotting Analysis: 1.0 ?g/mL of this antibody detected PACS2 in 10 ?g of rat hippocampus tissue lysate.
目标描述
~100 kDa observed
外形
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 9F12.2, monoclonal |
| species reactivity | mouse, rat |
| technique(s) | western blot: suitable |
| 同位素/亚型 | IgG1κ |
| NCBI登记号 | NP_001094383 |
| UniProt登记号 | Q86VP3 |
| 运输 | wet ice |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
