半岛bd体育手机客户端 说明
一般描述
OSTERIX, or SP7, is a zinc finger-containing, osteoblast-specific transcription factor that is distinctly expressed in all developing bones, and is a key requirement for the differentiation of pre-osteoblasts into fully functional osteoblasts. While research on the actual functional mechanisms of OSTERIX is still on-going, current findings indicate that OSTERIX expression is induced by BMP-2 and Dlx5, and operates downstream of RUNX2, supporting its role in mesenchymal stem cell differentiation. Further studies also indicate that the OSTERIX transcription factor may also play a role in negatively regulating the Wnt/β-catenin signaling pathways and the proliferation of osteroblast cell types during embryonic osteogenesis.
免疫原
GST-tagged recombinant protein corresponding to human Osterix.
应用
Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected Isocitrate dehydrogenase in rat tooth tissue. Nuclear staining may be observed in epithelial cells in some tissues.
Research Category
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Detect the Osterix (SP7) protein using this Anti-Osterix (SP7), clone 6B12.1 validated for use in WB & IHC.
质量
Evaluated by Western Blotting in SW1353 cell lysate.
Western Blotting Analysis: 1.0 ?g/mL of this antibody detected Osterix in 10 ?g of SW1353 cell lysate.
目标描述
~45 kDa observed. An uncharacterized band may appear at ~160 kDa in some lysates.
外形
Purified by Ion-Exchange Chromatography
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
SW1353 cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified antibody |
| antibody product type | primary antibodies |
| 克隆 | 6B12.1, monoclonal |
| species reactivity | rat, human |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| 同位素/亚型 | IgMκ |
| NCBI登记号 | NP_001166938 |
| UniProt登记号 | Q8TDD2 |
| 运输 | wet ice |
| Gene Information | human ... SP7(121340) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
