您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-OPA1, clone 1OPA-1A8 Antibody

Anti-OPA1, clone 1OPA-1A8 Antibody

品牌
Sigma-Aldrich
货号
MABN737
规格纯度
ascites fluid, clone 10PA-1A8, from mouse
价格
5688.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-OPA1, clone 1OPA-1A8 Antibody
Dynamin-like 120 kDa protein, mitochondrial, Large GTP-binding protein, LargeG, Optic atrophy protein 1 homolog, Dynamin-like 120 kDa protein, form S1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

OPA1 (optic atrophy 1) is a dynamin-related GTPase that plays a role in genome preservation and mitochondrial morphology. Localization of OPA1 is thought to be anchored to the inner membrane of the mitochondria. OPA1 is highly expressed in inner and outer retinal neurons and is important for normal mitochondrial function in those cells. Mutations in OPA1 are the major cause of autosomal dominant optic atrophy. Recent research has found that OPA1 also has the ability to protect neurons from excitotoxic injury and could be a potential clinical target to increase endurance of neurons post brain damage.

特异性

This antibody detects six known isoforms of OPA1 (Akepati, V. R., et al. (2008). J Neurochem. 106(1):372-383.).

免疫原

Recombinant protein corresponding to mouse OPA1.

应用

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected OPA1 in COS cells (Prof. Mustapha Oulad-Abdelghani, IGBMC, France).

Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated OPA1 from mouse brain tissue lysate (Akepati, V. R., et al. (2008). J Neurochem. 106(1):372-383.).
This Anti-OPA1 antibody, clone 1OPA-1A8 is validated for use in western blotting, ICC & IP for the detection of OPA1.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

质量

Evaluated by human brain tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected OPA1 in 10 ?g of human brain tissue lysate.

目标描述

~90 and ~100 kDa observed. Six isoforms between 80 kDa and 100 kDa are known to exist (Akepati, V. R., et al. (2008). J Neurochem. 106(1):372-383.).

外形

Unpurified
Mouse monoclonal IgG1κ ascites containing 0.05% sodium azide.

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 ascites fluid
antibody product type primary antibodies
克隆 10PA-1A8, monoclonal
species reactivity human, rat, mouse
technique(s) immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_598513
UniProt登记号 P58281
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map