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位置: 首页> 品牌> Sigma-Aldrich> Anti-NEZHA antibody, Mouse monoclonal

Anti-NEZHA antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200415
规格纯度
clone NEZHA-1, purified from hybridoma cell culture
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-NEZHA antibody, Mouse monoclonal
Anti-Calmodulin regulated spectrin-associated protein family member 3
Monoclonal Anti-NEZHA antibody produced in mouse
Anti-CAMSAP3
Anti-KIAA
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-NEZHA (mouse IgG1 isotype) is derived from the hybridoma NEZHA-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the C-terminal region of human NEZHA, conjugated to KLH. Nezha (a deity in Chinese mythology) also known as KIAA1543 and calmodulin-regulated spectrin associated protein, is a 1276 amino acid protein that contains one calponin homology (CH) and two coiled coil (CC1 and 2) domains, as well as one DUF1781 (DUF) domain of unknown function. NEZHA is mapped to human chromosome 19p13.
NEZHA/ calmodulin regulated spectrin associated protein family member 3 (CAMSAP3) contains a conserved domain called cholecystokinin (CKK) domain at carboxy-terminal, as well as several coiled-coil regions and an calponin homology domain at amino-terminal.

免疫原

synthetic peptide corresponding to a sequence at the C-terminal region of human NEZHA, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and dog NEZHA.

应用

Monoclonal Anti-NEZHA antibody produced in mouse has been used in immunofluorescence staining.
Monoclonal Anti-NEZHA antibody produced in mouse has been used in:

  • immunofluorescence
  • immunoprecipitation
  • immunofluorescence
  • mass-spectrometry-based analysis of a streptavidin pull-down assay
  • immunostaining

生化/生理作用

CAMSAP3 (calmodulin-regulated spectrin-associated protein 3)/ NEZHA modulates the minus-end dynamics of microtubules. It helps to maintain neuronal polarity. Absence of this gene results in the formation of supernumerary axon.
NEZHA/ calmodulin regulated spectrin associated protein family member 3 (CAMSAP3) facilitates translocation of Golgi vesicles in epithelial cells. In addition, it also helps in positioning the apical-to-basal polarity of microtubules in epithelial cells.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 NEZHA-1, monoclonal
形式 buffered aqueous solution
分子量 antigen ~150 kDa
species reactivity human, canine
浓度 ~1.0 mg/mL
technique(s) immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: 2.5-5.0 μg/mL using whole extracts of human SW480 cells
同位素/亚型 IgG1
UniProt登记号 Q9P1Y5
运输 dry ice
储存温度 ?20℃
Gene Information human ... CAMSAP3(57662)
mouse ... Camsap3(69697)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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