Anti-NDUFS3 Antibody, clone 6H7.1

半岛bd体育手机客户端 说明

一般描述

NDUFS3 is the core subunit of the mitochondrial respiratory chain′s NADH dehydrogenase complex, also known as Complex I, the complex critical for the production of ATP and NADH electron transfer. In mammals Complex I consists of some 45 different proteins, NDUFS3 is the critical core subunit of the complex. Expressed in all cells and localized in the mitochondria but encoded by a nuclear gene, NDUFS3 plays a critical role in electron transport, our internal cellular respiratory chain, and mitochondrial function. NDUFS3 also is important in disease phenotypes and various cancers. Mutations in NDUFS3 give rise to Leigh syndrome a mitochondrial dysfunctional disease. In cancers, down regulation of NDUFS3 is linked with lowered host survival and increased cancer pathology.

免疫原

GST-tagged recombinant protein corresponding to human NDUFS3.

应用

This Anti-NDUFS3 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of NDUFS3.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected NDUFS3 in human cerebral cortex, rat hippocampus, and rat cerebellum tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected NDUFS3 in 200 ?g of THP-1 cell lysate.

目标描述

~30 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	6H7.1, monoclonal
species reactivity	rat, human
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_004542
UniProt登记号	O75489
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable