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Anti-NDST4 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA011129
规格纯度
Prestige Antibodies?Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
价格
6389.73 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-NDST4 antibody produced in rabbit
Anti-Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 antibody produced in rabbit
Anti-Glucosaminyl N-deacetylase/N-sulfotransferase 4 antibody produced in rabbit
Anti-N-HSST 4 antibody produced in rabbit
Anti-N-heparan sulfate sulfotransferase 4 antibody produced in rabbit
Anti-NDST-4 antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

NDST4 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4) is the fourth member of NDST family, and shows high sequence homology to the other three members namely, NDST1, NDST2 and NDST3. It is made of 872 amino acids. This gene is localized to human chromosome 4q26, and alternative splicing gives rise to two isoforms of this protein. This protein is majorly expressed in developing embryos, and in adult brain. It is a type II transmembrane protein with 22 amino acids in the transmembrane region, and 12-13 amino acids in the cytoplasmic domain. It also shares two PAPS (3′-phosphoadenosine 5′-phosphosulfate) binding motifs, with other sulfotransferases.

免疫原

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

The functionality of NDST4 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4) is not yet characterized. It has higher sulfotransferase activity and lower deacetylase activity. It catalyzes the synthesis of heparan sulfate (HS) on existing proteins to form heparan sulfate proteoglycans (HSPGs). This gene is down-regulated in colorectal cancer (CRC), and is associated with advanced cancer phenotype. It is associated with invasiveness and metastasis of CRC, which might be an outcome of alterations in the HS chains of certain HSPGs. Therefore, NDST4 might have potential as a marker to predict the prognosis of CRC. This protein might be responsible for the addition of sulfate groups to glucosaminyl residues, which were deacetylated and left unaltered by other NDST members. Genome-wide association studies show that SNP near this gene is associated with maximum number of drinks (MaxDrinks), which is related to alcohol dependence.

特点和优势

Prestige Antibodies?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST71993.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

人类蛋白质图谱编号 HPA011129 Human Protein Atlas characterization data

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
半岛bd体育手机客户端 线 Prestige Antibodies?Powered by Atlas Antibodies
形式 buffered aqueous glycerol solution
species reactivity human
包装 antibody small pack of 25 μL
technique(s) immunohistochemistry: 1:50- 1:200
免疫原序列 GYKQEMTLIETTAEAECTDIKILPYRSMELKTVKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESSRFQ
UniProt登记号 Q9H3R1
运输 wet ice
储存温度 ?20℃
Gene Information human ... NDST4(64579)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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