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Anti-NDRG3 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4502492
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-NDRG3 antibody produced in rabbit
Protein NDRG3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

NDRG3 (N-myc downstream-regulated gene 3 protein) is a novel member of N-myc down-regulated gene (NDRG) family mapped to human chromosomal location 20q11.21-q11.23. It is abundantly expressed in brain, prostate, ovary, and testis tissues. It is localized to the outer layers of seminiferous epithelium.

免疫原

The antiserum was produced against synthesized peptide derived from human NDRG3.

Immunogen Range:206-255

应用

Anti-NDRG3 antibody produced in rabbit is suitable for immunohistochemistry and western blot.

生化/生理作用

N-myc downstream-regulated gene 3 protein (NDRG3) is involved in prostate cancer cell growthin vitroandin vivo. It acts as an androgen regulated and prostate enriched gene during controlling of cancer cell growth. Thus, overexpression of NDRG3 has been linked to the malignant phenotype of tumors. In hepatitis B virus (HBV)-related hepatocellular carcinoma cell line, NDRG3 gene is inversely expressed with the miR-122 expression. Thus, it has been reported that in conjugation with miR-122, NDRG3 can be a potential therapeutic marker for hepatocellular carcinoma (HCC). Prominent localization of NDRG3 in the epithelium cells indicate its role in spermatogenesis. It also plays an important role in lactate-induced hypoxia signaling pathway in hypoxia. Its protein level expression in cell is negatively regulated by oxygen, whereas, whereas excess lactate produced under prolonged hypoxia blocks its proteasomal degradation by binding to NDRG3.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 41 kDa
species reactivity rat, human, mouse
浓度 ~1 mg/mL
technique(s) ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号 Q9UGV2
UniProt登记号 Q9UGV2
运输 wet ice
储存温度 ?20℃
Gene Information human ... NDRG3(57446)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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