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位置: 首页> 品牌> Sigma-Aldrich> Anti-Myocilin (NT) Antibody, clone 7.1

Anti-Myocilin (NT) Antibody, clone 7.1

品牌
Sigma-Aldrich
货号
MABN866
规格纯度
clone 7.1, from mouse
价格
5520.38 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Myocilin (NT) Antibody, clone 7.1
Myocilin, Myocilin 55 kDa subunit, Trabecular meshwork-induced glucocorticoid response protein, Myocilin, N-terminal fragment, Myocilin 20 kDa N-terminal fragment
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Myocilin (mutated trabecular meshwork-induced glucocorticoid response protein) is encoded by the MYOC gene (also known as GLC1A, GPOA, JOAG, JOAG1, TIGR) in human (Entrez Gene ID 4653). Myocilin is produced as a 504 amino acid glycoprotein containing an N-terminal hydrophobic signal peptide sequence, a coiled-coiled leucine zipper domain, and a C-terminal domain with homology to olfactomedins. Myocilin is commonly identified as a 53/57 kDa doublet by gel electrophoresis, and a 66 kDa form of the protein is also reported. Myocilin is known to undergo intracellular endoproteolytic cleavage between Glu214 and Leu215, resulting in a 20 kDa N-terminal and a 35 kDa C-terminal fragment. Myocilin is identified as a Lingo-1 receptor ligand and MYOC gene mutations are linked to 10% of juvenile open-angle glaucoma cases and 3-4% of those with primary open-angle glaucoma (PMID 24732711 24741044, 24837143). Cat. No. MABN866, clone 7.1 is a mouse monoclonal antibody that recognizes an epitope within the N-terminal fragment (aa33-214) and is demonstrated to be suitable for Western blotting, immuncytochemistry, and immunhistochemistry applications. This clone is reactive toward both human and murine species. (PMID 18674535 & 23979599).

免疫原

Epitope: N-terminal fragment (aa 33-214)
Recombinant protein corresponding to the N-terminal fragment (aa 33-214) of human Myocilin.

应用

Research Category
Neuroscience
Immunohistochemistry Analysis: A representative lot detected Myocilin in human trabecular tissue (Ezzat, M.K., et al. (2008). Exp. Eye Res. 87(4):376-384).
Western Blotting Analysis: A representative lot detected Myocilin in human trabecular tissue (Ezzat, M.K., et al. (2008). Exp. Eye Res. 87(4):376-384).
Western Blotting Analysis: A representative lot detected Myocilin in aqueous humor (Zhao, Y., et al. (2013). Mol. Cell Biol. 33(21):4225-4240).
Anti-Myocilin Antibody, clone 7.1 is an antibody against Myocilin for use in Western Blotting, Immunohistochemistry.
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in mouse eye tissue lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected Myocilin in 10 ?g of mouse eye tissue lysate.

目标描述

~53, 60 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 7.1, monoclonal
species reactivity mouse, human
technique(s) immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_000252
UniProt登记号 Q99972
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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