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位置: 首页> 品牌> Sigma-Aldrich> Anti-MYLIP antibody produced in rabbit

Anti-MYLIP antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4501317
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-MYLIP antibody produced in rabbit
E3 ubiquitin-protein ligase MYLIP
MIR
Myosin regulatory light chain-interacting protein
Inducible degrader of the low-density lipoprotein receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The MYLIP (myosin regulatory light chain interacting protein) gene is mapped to human chromosome 6p22.3. The encoded protein is an E3 ubiquitin ligase, expressed in all tissues including hippocampus and cerebellum. Anti-MYLIP antibody detects endogenous levels of total MYLIP protein.

免疫原

The antiserum was produced against synthesized peptide derived from human MYLIP.

Immunogen Range:161-210

应用

Anti-MYLIP antibody produced in rabbit has been used in western blot analysis.

生化/生理作用

MYLIP (myosin regulatory light chain interacting protein) controls the LDLR (low density lipoprotein receptor) activity and stability, which might change due to fluctuation in the intracellular cholesterol levels. Mylip is associated with brain development. It induces platelet-derived growth factor (PDGF) signaling in fibroblasts. Mylip is also called as inducible degrader of the LDL-R (Idol), as it leads to receptor degradation, especially in macrophages and liver. It might serve as a target for drug development in disease.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 49 kDa
species reactivity rat, mouse, human
浓度 ~1 mg/mL
technique(s) ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号 Q8WY64
UniProt登记号 Q8WY64
运输 wet ice
储存温度 ?20℃
Gene Information human ... MYLIP(29116)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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