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Anti-MuSK Antibody

品牌
Sigma-Aldrich
货号
ABS549
规格纯度
serum, from rabbit
价格
5352.52 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-MuSK Antibody
Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

MuSK, also known as Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, or Muscle-specific kinase receptor, and encoded by the gene MUSK, a key muscle specific receptor tyrosine kinase that plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). The NMJ is the special synapse between the motor neuron and the skeletal muscle. MuSK activation in the myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in the subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors in the postsynaptic membrane. MuSK also plays a role in the CNS by mediating cholinergic responses, synaptic plasticity and memory function. MuSK is a membrane bound protein localized to the postsynaptic side of the cell membrane at the neuromuscular junction in muscle cells.

免疫原

Epitope: Extracellular domain
Recombinant protein corresponding to the extracellular domain of mouse MuSK.

应用

Western Blotting Analysis: A representative lot detected MuSK in C2C12 cell lysate (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunohistochemistry Analysis: A representative lot detected MuSK in mouse soleus muscle tissue (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunoprecipitation Analysis: A representative lot immunoprecipitated MuSK in C2C12 cell lysate (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Anti-MuSK antibody is an antibody against MuSK for use in western blotting, IHC & IP.

质量

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected MuSK in 10 ?g of HEK293 cell lysate.

目标描述

~110 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 serum
antibody product type primary antibodies
克隆 polyclonal
species reactivity human, mouse
technique(s) immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号 NP_001159752
UniProt登记号 Q61006
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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