Anti-MTSS1 Antibody, clone 15C3.2

半岛bd体育手机客户端 说明

一般描述

Metastasis suppressor protein 1 (UniProt O43312; also known as Metastasis suppressor YGL-1, Missing in metastasis protein) is encoded by the MTSS1 (also known as KIAA0429, MIM) gene (Gene ID 9788) in human. MTSS1 is a scaffold protein that regulates cytoskeletal dynamics and actin polymerization. MTSS1 is also reported to bind Gli proteins or the Gli-Sufu complex and potentiate the transcription of effector genes of the sonic hedgehog signaling pathway. MTSS1 is down-regulated in many metastatic cancer cells compared with their non-metastatic counterparts. MTSS1 expression is shown to be inversely correlated with the prognosis of solid carcinomas of the breast, liver, and bladder.

特异性

This clone is expected to react with all 4 spliced isoforms of human MTSS1.

免疫原

GST-tagged recombinant protein corresponding to the C-terminal of human MTSS1.
Epitope: C-terminal

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MTSS1 in human colon and human spleen tissues.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Detect MTSS1 using this mouse monoclonal Anti-MTSS1 Antibody, clone 15C3.2, Cat. No. MABC607, validated for use in Western Blotting and Immunohistochemistry (Paraffin).

质量

Evaluated by Western Blotting in COS-1 cell lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected MTSS1 in 10 ?g of COS-1 cell lysate.

目标描述

~82 kDa observed

外形

Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss

32160702

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	15C3.2, monoclonal
species reactivity	human, monkey
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_055566
UniProt登记号	O43312
运输	wet ice
Gene Information	human ... MTSS1(9788)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable