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位置: 首页> 品牌> Sigma-Aldrich> Anti-MSN Antibody, clone 2C12

Anti-MSN Antibody, clone 2C12

品牌
Sigma-Aldrich
货号
MABT456
规格纯度
ascites fluid, clone 2C12, from mouse
价格
5854.74 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-MSN Antibody, clone 2C12
Moesin, Membrane-organizing extension spike protein
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Moesin (membrane-organizing extension spike protein) is the protein encoded by the MSN gene. The MSN encoded protein moesin is a member of the ERM (ezrin, moesin, radixin) family of proteins that regulate linkage between the plasma membrane and the actin cytoskeleton. Thus, the MSN encoded protein is a peripheral membrane protein that is keenly involved in the signaling and structural connections in cytoskeletal plasma membrane structures like microvilli. Moesin in its active, phosphorylated state strongly binds actin and helps anchor it to the plasma membrane. The MSN encoded Moesin is localized to filopodia and other membranous extensions of various cell types and thus plays a role in cell-cell recognition signaling, cell movement, and cell transport. In its inactive, non-phosphorylated state, Moesin binds itself in a head-tail fashion and is incapable of binding actin or other cytoskeletal proteins. The kinase ROCK2 is central to the opening up of moesin and allowing its interaction with actin and the plasma membrane. EMD-Millipore’s Anti-MSN, clone 2C12 has been tested in western blots against purified recombinant protein as well as multiple human cancer cell lysates. The clone has also been tested successfully in paraffin embedded immunohistochemistry on human colon tissue and by flow cytometry on human Jurkat cells and ELISA using purified recombinant antigen.

免疫原

Purified protein fragment of human MSN expressed in E. coli.

应用

Detect Moesin using this mouse monoclonal antibody, Anti-MSN Antibody, clone 2C12 validated for use in western blotting, IHC & Flow Cytometry.
Immunohistochemistry Analysis: A 1:100-1,000 dilution from a representative lot detected MSN in human tonsil and colon tissues.

Flow Cytometry Analysis: A 1:200-400 dilution from a representative lot detected MSN in Jurkat cells.

Optimal working dilutions must be determined by end user.

质量

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected MSN in 10 ?g of Jurkat cell lysate.

目标描述

~68 kDa observed. Uncharacterized bands may appear in some lysate(s).

外形

Unpurified

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 ascites fluid
antibody product type primary antibodies
克隆 2C12, monoclonal
species reactivity human
technique(s) flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG1
NCBI登记号 NP_002435
UniProt登记号 P26038
运输 wet ice
Gene Information human ... MSN(4478)

安全信息

象形图 GHS08
警示用语: Danger
危险声明 H360D - H412
预防措施声明 P201 - P202 - P273 - P280 - P308 + P313 - P405
危险分类 Aquatic Chronic 3 - Repr. 1A
储存分类代码 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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