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位置: 首页> 品牌> Sigma-Aldrich> Anti-MOZ/MYST3 (N-term) antibody produced in rabbit

Anti-MOZ/MYST3 (N-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300152
规格纯度
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
价格
4618.16 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-MOZ/MYST3 (N-term) antibody produced in rabbit
Anti-Histone acetyltransferase MYST3
Monocytic leukemia zinc finger protein
Runt-related transcription factor-binding protein 2
Anti-MYST protein 3
Anti-MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

MOZ (monocytic leukemia zinc finger protein) is also known as lysine acetyltransferase 6 (KAT6A) and belongs to the MYST (MOZ, YBF2/SAS3, SAS2 and TIP60) family. The KAT6 gene is mapped to human chromosomes 8p11.21. The structure of KAT6 is evolutionarily conserved in organisms ranging from yeast to mammals. The encoded protein contains a nuclear localization domain (including H15), a histone-acetyltransferase domain (HAT), an acidic glutamate/aspartate-rich region, a double-plant homeodomain finger that interacts with acetylated histone H3 tails (PHD 1 and 2) and a serine and methionine-rich region containing a transactivation domain. In humans, the gene is broadly expressed in different tissues, strongly in the brain and low in the heart.
MOZ/MYST3 is a histone acetyltransferase which may act as a transcriptional coactivator for RUNX1 and RUNX2.

免疫原

MOZ/MYST3 (NP_001092882, 72-108)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MYST3.

生化/生理作用

KAT6A (lysine acetyltransferase 6A) is a histone acetyltransferase. It is a transcriptional co-activator. It acetylates histone H3 at K14 and K9 and H4 at K5, K8, K12 and K16in vitro. KAT6A is associated with the regulation of cell cycle and stem cell homeostasis. In acute myeloid leukemia the involvement of KAT6A along with CREB binding protein has been observed. KAT6A acts as an oncogene. Mutations and abnormal regulation in KAT6 gene is associated with solid tumors and developmental disorders in human. It serves as a key epigenetic regulator of hematopoiesis. Mutations in the gene lead to abnormal acetylation of K9 and K18 of histone3 as well as changes in the P53 signaling. Therefore, affecting multiple cellular processes and controlling disease conditions.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 saturated ammonium sulfate (SAS) precipitated
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human
technique(s) immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBI登记号 NP_001092882
UniProt登记号 Q92794
运输 dry ice
储存温度 ?20℃
Gene Information human ... MYST3(7994)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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