半岛bd体育手机客户端 说明
一般描述
The gene TLR3 (toll like receptors) is mapped to human chromosome 4q35.1. Tlrs are predominantly expressed in antigen-presenting cells (APCs) such as macrophages and dendritic cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
免疫原
TLR3 (Q99MB1, 28-63)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of mouse TLR3.
生化/生理作用
Toll-like receptors (TLRs) are essential element of nonspecific innate inflammatory response. Tlr3 is a pathogen recognition receptor that recognizes dsRNA of viruses and induces an innate immune response against the pathogen. It recognizes damage-associated and pattern-associated molecular pattern molecules. TLRs induce immune tolerance by activating transcription factors and the expression of downstream genes. TLRs maintain immune homeostasis by identification and rejection of self-senescent and pathological cells. Tlr3 is expressed in high levels on several cancer type cells and serves as an immunotherapeutic target to initiate both innate and adaptive immune responses. Tlr3 possesses anti-tumoral potential by inducing a strong type I interferon response. Tlr3 is known to induce strong CD8+T cell (cytotoxic T lymphocytes) responses by promoting cross-priming of endogenous antigens. TLR3 is known to mediate hippocampal memory. Due to its wide expression in the mesolimbic dopamine system, TLR3 signaling might control alcohol consumption.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | mouse |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 |
| NCBI登记号 | NP_003256 |
| UniProt登记号 | Q99MB1 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
