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位置: 首页> 品牌> Sigma-Aldrich> Anti-monomethyl Histone H2A (Gln104)

Anti-monomethyl Histone H2A (Gln104)

品牌
Sigma-Aldrich
货号
ABE1332
规格纯度
from rabbit, purified by affinity chromatography
价格
6011.69 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-monomethyl Histone H2A (Gln104)
Histone H2A type 1, Gln104 monomethylated, H2A.1, Gln104 monomethylated, Histone H2A/p, Gln104 monomethylated, H2AQ104me, Gln104 monomethylated
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Histone H2A type 1 (UniProt P0C0S8; also known as H2A.1, Histone H2A/p) is encoded by the HIST1H2AG (also known as H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2AM, H2AFN) gene (Gene ID 8969) in human. Histone H2A is one of four components of the core nucleosome structure. The nucleosome represents a unit of chromatin in which DNA is wrapped around a histone octamer. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones. Histones undergo a number of post-translational modifications in response to various stimuli that may induce changes in the structure of the nucleosome and hide or expose DNA sequences. Histone H2A, in particular, undergoes acetylation on lysine 5 by Tip60 enzyme, which may promote unfolding of chromatin and transcription. In addition, H2A is phosphorylated on serine 1 and serine 139 (H2A.X) residues, which mark mitosis and gene repression and DNA damage, respectively. Gene repression may also result from the sumoylation of H2A s lysine 126 residue. In addition, ubiquitination of the H2A lysine 119 residue may play a role in spermatogenesis. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.

特异性

Specificity of this polyclonal antibody was verified by dot blot analysis. This polyclonal antibody specifically detected peptide corresponding to histone H2A target region sequence with monomethylated Gln104 (Q104me), but not H2A peptides without Q104me modification, nor peptides derived from histone H1, H2A.Z, H2B, H3, H3.3, or H4 sequences.

免疫原

KLH-conjugated linear peptide corresponding to human histone H2A target region sequence containing monomethylated Gln104 (Q104me).

应用

Research Category
Epigenetics & Nuclear Function
Anti-monomethyl Histone H2A (Gln104) Antibody, Cat. No. ABE1332, is a highly specific rabbit polyclonal antibody that targets histone H2A Gln104 monomethylation (Q104me) and has been tested by histone peptide array Dot Blot.

质量

Evaluated by Dot Blot Analysis of histone peptide array.

Dot Blot Analysis: A 1:200 dilution of this antibody detected 4-40 ng of histone H2A peptide containing monomethylated Gln104 (Q104me).

目标描述

13.96 kDa (Met1 removed) calculated.

外形

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Affinity purified.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) dot blot: suitable
NCBI登记号 NP_003500
UniProt登记号 P0C0S8
运输 ambient
Gene Information human ... HIST1H2AG(8969)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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