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Anti-MMP7 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV46075
规格纯度
IgG fraction of antiserum
价格
3311.54 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-MMP7 antibody produced in rabbit
Anti-PUMP-1
Anti-MPSL1
Anti-MMP-7
Anti-Matrix metallopeptidase 7 (matrilysin, uterine)
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Matrix metallopeptidase 7 (matrilysin, uterine) (MMP7) is an extracellular matrix remodeling enzyme that catalyzes the degradation of interstitial proteoglycans such as fibronectin, elastin and casein. As a remodeling enzyme, MMP7 is involved in normal physiological processes such as embryonic development, reproduction, tissue remodeling and wound healing. MMP7 is also involved in diseases that involve matrix remodeling or destruction such as arthritis and tumor metastasis.

特异性

Anti-MMP7 polyclonal antibody reacts with bovine and human matrix metallopeptidase 7 proteins.

免疫原

Synthetic peptide directed towards the C terminal region of human MMP7

应用

Anti-MMP7 polyclonal antibody is used to tag matrix metallopeptidase 7 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of matrix metallopeptidase 7 in matrix remodeling in both normal and pathological processes such as metastasis.

生化/生理作用

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP′s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP7 degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP′s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

序列

Synthetic peptide located within the following region: AATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGK

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
分子量 19 kDa
species reactivity sheep, human
浓度 0.5 mg - 1 mg/mL
technique(s) western blot: suitable
NCBI登记号 NP_002414
UniProt登记号 P09237
运输 wet ice
储存温度 ?20℃
Gene Information human ... MMP7(4316)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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