Anti-MEPE Antibody, clone LFMb-33

半岛bd体育手机客户端 说明

一般描述

The protein with the gene name MEPE and the protein name of Matrix extracellular phosphoglycoprotein or Osteoblast/osteocyte factor 45 (OF45) is an important secreted protein expressed by osteoblasts which promotes mineralization in bone. New research interestingly indicates that cancer cells that over express MEPE/OF45 show an increased resistance to radiation therapy, thus OF45 is being examined as a potentially new target for sensitizing tumor cells to radiochemotherapy. MEPE/OF45 is highly expressed by osteoblasts and osteocytes and my multiple cancer cell types and regulated by growth factors such as FGF-2 which acts to lower expression of the protein in normal cells.

免疫原

Recombinant protein corresponding to human MEPE.

应用

Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: 1.0 ?g/mL from a representative lot detected MEPE in 10 ?g of SK-N-SH and U2OS cell lysate.
Immunohistochemistry Analysis: A representative lot detected MEPE in human salivary gland tissue (Dent, J., et al. (2004). Research. 83(9):664-670).
Anti-MEPE Antibody, clone LFMb-33 | MABC540 is an antibody against MEPE Antibody for use in Western Blotting, Immunohistochemistry.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected MEPE in 10 ?g of HeLa cell lysate.

目标描述

~65 kDa observed. The calculated molecular weight of this protein is 58 kDa, but can be observed at ~45-62 kDa due to high glycosylation.

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	LFMb-33, monoclonal
species reactivity	human, mouse
technique(s)	immunohistochemistry: suitable western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_001171623
UniProt登记号	Q9NQ76
运输	wet ice
Gene Information	human ... MEPE(56955)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable