半岛bd体育手机客户端 说明
一般描述
Anti-MEKKK 1 Antibody detects endogenous levels of total MEKKK 1 protein. The MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) gene is mapped to human chromosome 5q11.2 and codes for serine/threonine kinase protein containing a plant homeodomain.
免疫原
The antiserum was produced against synthesized peptide derived from human MEKKK 1.
Immunogen Range:371-420
生化/生理作用
MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) controls different processes associated with inflammation and apoptosis. In response to upstream signals, the members of the MAPK (mitogen-activated protein kinase) family gets activated upon phosphorylation. MEKKK 1 possesses E3 ubiquitin ligase activity in relation to c-Jun protein stability and regulates the JNK (c-Jun NH2-terminal kinases) pathway. MEKKK 1 gene regulation is associated with acute respiratory distress syndrome.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
基本信息
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
分子量 | antigen 91 kDa |
species reactivity | human, mouse |
浓度 | ~1 mg/mL |
technique(s) | ELISA: 1:10000 western blot: 1:500-1:1000 |
NCBI登记号 | Q92918 |
运输 | wet ice |
储存温度 | ?20℃ |
Gene Information | human ... MAP3K1(4214) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | nwg |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich