半岛bd体育手机客户端 说明
一般描述
MD-1 is a lymphocyte antigen 86 (LY86). The mature peptide is a secretory molecule, has 143 amino acids with no hydrophobic stretches. It has two N-terminal glycosylation sites. Human Md-1 is homologous to mice and chicken Md-1. Out of seven cysteine residues, six is conserved in all three species. MD-1 protein is expressed on the cell surface and lacks transmembrane region. MD-1/Radioprotective 105(RP105) complex is expressed on cell surfaces of B-cells, dendritic cells and macrophages. In human chromosome, the gene MD-1 is localised on 6p25.1.
免疫原
a 15 amino acid peptide from near the center of human MD-1.
生化/生理作用
MD-1 associates with Radioprotective 105 (RP105) protein. MD-1 mediates cell surface expression of RP105. Together MD-1 and RP105 are required for lipopolysaccharide (LPS) recognition and signalling. Lack of MD-1 leads to reduced responsiveness to microbial membrane/LPS in B cells. Expression of MD-1 in dendritic cells and macrophages leads to inhibition of TLR4 (Toll like receptor 4)/MD-2 responsiveness to LPS. Methylation of LY86 gene causes obesity and plays a key role in obesity related metabolic disorder.
联系
The action of this antibody can be blocked using blocking peptide SBP3851.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD03845542 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human, mouse, rat |
| technique(s) | immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable |
| UniProt登记号 | O95711 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... LY86(9450) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
