Anti-Mcpip1, clone 2H8.2 Antibody

半岛bd体育手机客户端 说明

一般描述

MCP-induced protein 1 (also known as ribonuclease ZC3H12A, Zinc finger CCCH domain-containing protein 12A) is encoded by the ZC3H12A gene in human (also known as dJ423B22.1, MCPIP, MCPIP1). It belongs to the 4-member CCCH-zinc finger protein family (MCPIP1/2/3/4) that act as negative regulators in macrophage activation (PMID 18178554). MCPIP1 in particular is involved in immune response downregulation upon LPS treatment by targeting IL-6 and IL-12b with its RNase activity (PMID 22561375). MCPIP1 expresssion by MCP-1 treatment is reported to promote angiogenesis in human umbilical vein endothelial cell (HUVEC) cultures, while causing apoptotic cell death in cardiac myocytes (PMID 18364357 & 16574901).

免疫原

GST-tagged recombinant protein corresponding to human Mcpip1.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MCPIP1 in human kidney tissue.
Anti-Mcpip1, clone 2H8.2 Antibody is an antibody against Mcpip1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).

质量

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected MCPIP1 in 10 ?g of THP-1 cell lysate.

目标描述

~65 kDa observed

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	2H8.2, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_079355
UniProt登记号	Q5D1E8
运输	wet ice
Gene Information	human ... ZC3H12A(80149)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable