半岛bd体育手机客户端 说明
一般描述
Mini chromosome maintenance protein 2 (MCM2) is a human nuclear protein. This cell-cycle regulatory protein is similar to members of the family of early S-phase proteins and is expressed in four phases of the cell cycle. MCM2 gene is mapped to human chromosome 3q21.3. MCM2 protein is a member of eukaryal MCM2–7 subunits and is expressed in the nucleus and cytoplasm of various tissues.
免疫原
Synthetic peptide derived from internal region of human MCM2 protein.
生化/生理作用
Mini chromosome maintenance protein 2 (MCM2) is involved in regulating DNA replication, is crucial in the cell cycle. From its localization, CDCL1 is a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML). MCM-2 levels are elevated in salivary gland tumors and malignant lesions of the oral cavity. It serves as a marker for the detection of oral squamous cell carcinoma (OSCC). MCM2 overexpression also displays pro-apoptotic and apoptotic. MCM2 is also implicated in nonsyndromic hearing loss.
特点和优势
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外形
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 重组 | expressed in proprietary host |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | SP85, monoclonal |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | rat, bovine, dog, mouse, frog |
| technique(s) | flow cytometry: 1:100 immunoblotting: 1:100 immunohistochemistry: 1:100 |
| 同位素/亚型 | IgG |
| UniProt登记号 | P49736 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... MCM2(4171) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
