Anti-MBNL2 Antibody, clone MB2a(3B4)

半岛bd体育手机客户端 说明

一般描述

MBNL2, also known as Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, or Muscleblind-like protein-like 39, and encoded by the gene MBNL2/MBLL/MBLL39/MLP1, is a protein that mediates pre-mRNA alternative splicing regulation. MBNL2 acts either as an activator or repressor of splicing on specific pre-mRNA targets. For instance MBNL2 inhibits cardiac troponin-T pre-mRNA exon inclusion but induces insulin receptor pre-mRNA exon inclusion in muscle. MBNL2 may also regulate ITGA3 expression by transporting it from the nucleus to cytoplasm at adhesion plaques. MBNL2 appears to play a key role in the muscle disease named myotonic dystrophy pathophysiology. MBNL2 is expressed in the nucleus of cells in multiple tissues but can be found in the cytoplasm in certain situations. In particular it is found in the cytoplasm in adhesion plaques.

免疫原

Recombinant protein corresponding to human MBNL2.

应用

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Nuclear Receptors
This Anti-MBNL2 Antibody, clone MB2a(3B4) is validated for use in Western Blotting for the detection of MBNL2.

质量

Evaluated by Western Blotting in C2C12 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected MBNL2 in 10 ?g of C2C12 cell lysate.

目标描述

~40 kDa observed

外形

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	MB2a(3B4), monoclonal
species reactivity	mouse
species reactivity (predicted by homology)	human (based on 100% sequence homology)
浓度	1 mg/mL
technique(s)	western blot: suitable
同位素/亚型	IgG2bκ
NCBI登记号	NP_659002
UniProt登记号	Q5VZF2
运输	wet ice
Gene Information	human ... MBNL2(10150)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable