半岛bd体育手机客户端 说明
一般描述
MART-1 (melanoma antigen recognized by T cells) is also termed as Melan-A. It is a type III membrane protein with a molecular weight of 22-24 kDa. It is present in the endoplasmic reticulum (ER), trans-Golgi network (TGN) and in melanosomes. MART-1 is a melanocyte lineage protein. This gene is mapped to human chromosome 9p24.1.
Melanoma-associated antigen recognized by T cells-1 (MART-1) (also known as Melan-A) is a melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. It is a transmembrane protein which is hydrophobic in nature. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, Tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. The protein is also expressed in melanoma tumors. Anti-MART-1 Antibody detects endogenous levels of total MART-1 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human MART-1.
Immunogen Range:41-90
生化/生理作用
MART-1 (melanoma antigen recognized by T cells) is essential for the activities of the melanosomal matrix protein PMEL17 (premelanosome protein)/GP100 and the maturation of melanosomes. It plays a key role in pigmentation. MART-1 plays an important role in the expression, stability, trafficking and processing of Pmel17.
Melanoma-associated antigen recognized by T cells-1 (MART-1) has been shown to be essential for the functioning of glycoprotein-100 (gp100).
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD01633630 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 13 kDa |
| species reactivity | human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:40000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | Q16655 |
| UniProt登记号 | Q16655 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... MLANA(2315) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
