Anti-MAFA Antibody

半岛bd体育手机客户端 说明

一般描述

MAFA is a tissue specific transcription factor found in the nuclei of pancreas islet beta cells. MAFA specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. MAFA also cooperates synergistically with NEUROD1 and PDX1 in enhancing additional gene expression during development as well. Phosphorylation by GSK3 increases MAFA transcriptional activity and is required for its oncogenic activity. MAFA can be either an oncogene or act as a tumor suppressor, depending on the cell context.

特异性

Recognizes MAFA

免疫原

Mixture of three linear peptides corresponding to amino acids 1-150 of human MAFA.
Epitope: Region near the N-terminus of MAFA

应用

Research Sub Category
Transcription Factors
This Anti-MAFA Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of MAFA.
Research Category
Epigenetics & Nuclear Function
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot was reported to detect MAFA in HeLa, 293T/17, Capan-2, SAOS-2, SH-SY5Y, and Skin 3, 44 cells.

质量

Evaluated by Western Blotting in a HEK293T cell lysate.

Western Blotting Analysis: A 1 ?g/mL dilution of this antibody detected MAFA in a 293T cell lysate.

目标描述

~ 35 kDa observed

外形

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
technique(s)	immunocytochemistry: suitable western blot: suitable
NCBI登记号	NP_963883
UniProt登记号	Q8NHW3
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable