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位置: 首页> 品牌> Sigma-Aldrich> Anti-LZTR2 Antibody

Anti-LZTR2 Antibody

品牌
Sigma-Aldrich
货号
ABS442
规格纯度
from rabbit, purified by affinity chromatography
价格
4742.47 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-LZTR2 Antibody
Leucine zipper-like transcription regulator 2, SEC16B, RGPR, RGPR-p117, KIAA1928, LZTR2, SEC16S, Regucalcin gene promoter region-related protein p117, Protein transport protein Sec16B, SEC16 homolog B
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Leucine zipper-like transcription regulator 2 (LZTR2), also known as RGPR-p117, is a member of the SEC16 family and BTB-kelch superfamily. LZTR2 is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization. Initially, it was described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is localized in the cytoplasm but is thought to translocate to the nucleus following a hormonal stimulation and mediated by protein kinase C signaling. Recent studies has suggested that there is a strong correlation between LZTR2 and obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations. This evidence implies that LZTR2 may play an important role in metabolism and obesity risk.

免疫原

KLH-conjugated linear peptide corresponding to human LZTR2.

应用

Research Sub Category
Metabolic Hormones & Receptors
Research Category
Signaling
Anti-LZTR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Leucine zipper-like transcription regulator 2 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: 5 ?g/mL from a representative lot detected LZTR2 in mouse kidney tissue.

质量

Evaluated by Western Blotting in mouse kidney tissue lysate.

Western Blotting Analysis: 1 ?g/mL of this antibody detected LZTR2 in 15 ?g of mouse kidney tissue lysate.

目标描述

~92 kDa and ~140 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~59 kDa, ~71 kDa, and ~117 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Mouse kidney tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity mouse
species reactivity (predicted by homology) human (immunogen homology)
technique(s) immunohistochemistry: suitable
western blot: suitable
UniProt登记号 Q96JE7
运输 wet ice
Gene Information human ... SEC16B(89866)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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