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Anti-LXN antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA014179
规格纯度
Prestige Antibodies?Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
价格
2808.5 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-LXN antibody produced in rabbit
Anti-Latexin
Anti-TCI
Anti-Endogenous carboxypeptidase inhibitor
Anti-MUM
Anti-Tissue carboxypeptidase inhibitor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The gene LXN (latexin) encodes a 222-residue that contains two topologically equivalent subdomains with an α-helix surrounded by a curved β-sheet. A third α-helix forms a connection linking the subdomains. It is also called as tissue or endogenous carboxypeptidase inhibitor (CPI) and is predominantly expressed in the heart, prostate, ovary, kidney, pancreas, and colon and to some extent in the brain. The encoded protein is larger than plant and parasite CPIs and does not contain the conserved 7-residue C terminus that is present in the shorter CPIs. This indicates that the mechanism of CPA inhibition varies between latexin and plant/parasite CPIs. The gene is mapped to human chromosome 3q25.32.

免疫原

Latexin recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

Latexin (LXN) is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) in mammals. It functions as a global inhibitor of vertebrate A/B MCPs. Mammalian latexin was recognized as a marker of neurons in the lateral neocortex of the developing brain. The protein has been crucial in the determination of the mechanism of cortical regional specification. It has been implicated in the modulation of sensory perception. It is induced in acute pancreatitis and lung inflammatory disease, which suggests its role in inflammation and innate immune pathways.

特点和优势

Prestige Antibodies?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST71482.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

人类蛋白质图谱编号 HPA014179 Human Protein Atlas characterization data

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
半岛bd体育手机客户端 线 Prestige Antibodies?Powered by Atlas Antibodies
形式 buffered aqueous glycerol solution
species reactivity mouse, rat, human
包装 antibody small pack of 25 μL
增强验证 RNAi knockdown
Learn more aboutAntibody Enhanced Validation
technique(s) immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
免疫原序列 MEIPPTNYPASRAALVAQNYINYQQGTPHRVFEVQKVKQASMEDIPGRGHKYHLKFAVEEIIQKQVKVNCTAEVLYPSTGQETAPEVNFTFEGETGKNPDEEDNTF
UniProt登记号 Q9BS40
运输 wet ice
储存温度 ?20℃
Gene Information human ... LXN(56925)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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