Anti-LOX-1, clone 9E12.1

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一般描述

LOX1 is a plasma membrane receptor, that also has a free soluble receptor form, that is the receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. LOX1 is also the receptor for HSP70, and LOX1 acts as a leukocyte adhesion molecule on glycosylated proteins present on platelets, monocytes, bacteria, apoptotic cells in inflammatory responses.

免疫原

GST-tagged recombinant protein corresponding to human LOX-1.

应用

Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Anti-LOX-1 Antibody, clone 9E12.1 is an antibody against LOX-1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LOX-1 in human placenta tissue.

质量

Evaluated by Western Blotting in KG-1 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected LOX-1 in 200 ?g of KG-1 cell lysate.

目标描述

~35 kDa observed. The calculated molecular weight of this protein is 31 kDa, but can be observed at ~33-37 kDa due to high glycosylation.

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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