Anti-LGI1 Antibody

半岛bd体育手机客户端 说明

一般描述

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are very similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms.

特异性

This antibody recognizes only Isoform 1.

免疫原

KLH-conjugated linear peptide corresponding to human LGI1.

应用

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Western Blot Analysis: 2 ?g/mL from a representative lot detected LGI1 in 10 ?g/mL of HEK293 cell lysate.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected LGI1 in mouse cerebellum and rat cortex tissues.
Detect the LGI1 protein using this Anti-LGI1 validated for use in WB & IHC.

质量

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 2 ?g/mL of this antibody detected LGI1 in 10 ?g/mL of mouse brain tissue lysate.

目标描述

~64 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa An uncharacterized band may appear at ~45 kDa in some lysates.

外形

Format: Purified
Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Mouse brain tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
species reactivity	rat, mouse, human
technique(s)	immunohistochemistry: suitable western blot: suitable
UniProt登记号	O95970
运输	wet ice
Gene Information	human ... LGI1(9211)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable