Anti-LAR/PTPRF Antibody, clone N165/38

半岛bd体育手机客户端 说明

一般描述

Receptor-linked protein-tyrosine phosphatases (RPTPs) are signaling proteins that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. Leukocyte common antigen receptor protein tyrosine phosphatase (LAR/PTPRF), a negative regulator of several receptor tyrosine kinases, is present in high concentrations in mature synapses and is considered to be important for the development and maintenance of excitatory synapses in hippocampal neurons. Disruption of LAR function is shown to result in loss of excitatory synapses, diminution in surface AMPA receptors, and impairment of dendritic targeting of the cadherin–beta-catenin complex. LAR is also present in neurons expressing TrkB where it participates in survival of neurons and the neurite outgrowth. Increased expression of LAR in insulin-responsive tissues has also been associated with obesity and insulin resistance.

特异性

Other Homologies: Mouse (97% sequence homology).
This antibody does not cross-react with PTPRD and PTPRS (Prof. J. Trimmer, University of California, Davis.).

免疫原

Recombinant protein corresponding to human LAR/PTPRF.

应用

Research Sub Category
Synapse & Synaptic Biology
Anti-LAR/PTPRF Antibody, clone N165/38 is a highly specific mouse monoclonal antibody & that targets LAR & has been tested in western blotting.
Research Category
Neuroscience

质量

Evaluated by Western Blotting in rat brain membrane tissue.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected LAR/PTPRF in 10 ?g of rat brain membrane tissue.

目标描述

~78 kDa observed. The full length protein is 210 kDa; however, it runs lower in Western Blotting due to proteolysis into P-subunit containing transmembrane and intracellular domains (Prof. J. Trimmer, University of California, Davis).

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Rat brain membrane tissue

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	N165/38, monoclonal
species reactivity	rat
technique(s)	western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_002831
UniProt登记号	P10586
运输	wet ice
Gene Information	human ... PTPRF(5792)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable