Anti-KRIT-1 Antibody, clone 15

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一般描述

Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, results from autosomal dominant CCM1 mutations that cause a loss of KRIT-1 protein function. CCM1 has been identified as the KRIT-1 gene. The protein product, KRIT-1, also known as Krev interaction trapped protein 1, is a microtubule-associated protein involved in endothelial cell-cell and cell-extracellular matrix interactions. KRIT-1 binds to Rap1 that maintains the integrity of endothelial junctions. It is reported that KRIT-1 colocalizes and is physically associated with junctional proteins via its band 4.1/ezrin/radixin/moesin (FERM) domain, (Glading, 2007).

特异性

The antibody recognizes KRIT-1.

免疫原

Epitope: FERM domain
GST-tagged recombinant protein corresponding to human KRIT-1 at and around the FERM domain.

应用

Research Category
Cell Structure
Anti-KRIT-1 Antibody, clone 15 detects level of KRIT-1 & has been published & validated for use in IC, IP & WB.
Research Sub Category
Adhesion (CAMs)

质量

Immunocytochemistry Analysis: 1:500 dilution of this antibody detected KRIT-1 in HeLa, A431, and HUVECs.

目标描述

~ 84 kDa

外形

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HeLa, A431, and HUVECs.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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