Anti-KI-67 antibody, Rabbit monoclonal

半岛bd体育手机客户端 说明

一般描述

The gene marker of proliferation Ki-67 (MKI67), spanning 15 exons, is mapped to human chromosome 10q26.2. The encoded protein contains phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal. It possesses 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.
Ki-67 is a nuclear protein, which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.

免疫原

Synthetic peptide from C-terminus of human Ki-67 protein.

应用

Anti-KI-67 antibody, Rabbit monoclonal has been used in immunohistochemistry.

生化/生理作用

Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, functions as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered to be a potent cell proliferation marker.

特点和优势

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外形

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
重组	expressed in proprietary host
偶联物	unconjugated
抗体形式	tissue culture supernatant
antibody product type	primary antibodies
克隆	SP6, monoclonal
species reactivity	human (tested)
species reactivity (predicted by homology)	bovine
technique(s)	immunohistochemistry: 1:200
同位素/亚型	IgG
UniProt登记号	P46013
运输	wet ice
储存温度	2-8℃
Gene Information	human ... MKI67(4288)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable