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Anti-Keratin 17 antibody, Rabbit monoclonal

品牌
Sigma-Aldrich
货号
SAB5500125
规格纯度
clone SP95, recombinant, expressed in proprietary host, affinity isolated antibody
价格
4661.96 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Keratin 17 antibody, Rabbit monoclonal
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Keratin 17 plays a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. It may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" and also act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. It is required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state and modulates the function of TNF-alpha in the specific context of hair cycling. It regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway and is involved in tissue repair. Keratin 17 is expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. It is also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).

免疫原

Synthetic peptide corresponding to C-terminus of human keratin 17 protein.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
重组 expressed in proprietary host
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 SP95, monoclonal
species reactivity human (tested)
species reactivity (predicted by homology) bovine, mouse, dog, rat
technique(s) flow cytometry: 1:100
immunoblotting: 1:25
immunohistochemistry: 1:100
同位素/亚型 IgG
UniProt登记号 Q04695
运输 wet ice
储存温度 2-8℃
Gene Information human ... KRT17(3872)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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